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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/7527

Title: REVIEW ARTICLE - WHAT WE KNOW ABOUT THE MOLECULAR GENETICS OF CENTRAL NERVOUS SYSTEM (CNS) TUMOURS IN MALAYSIA
Authors: Sulong, Sarina
Yusoff, Abdul Aziz Mohamed
Zainuddin, Norafiza
Abdullah, Jafri Malin
Pannatil, Jain George
Jaafar, Hasnan
Isa, Mohd Nizam
Keywords: molecular genetics, CNS tumours, Malaysia
Issue Date: 31-Dec-2004
Publisher: School of Medical Sciences, Universiti Sains Malaysia
Citation: Malaysian Journal of Medical Sciences (ISSN: 1394-195X) Vol 11 Num 1
Abstract: The new millennium has been regarded as a genomic era. A lot of researchers and pathologists are beginning to understand the scientific basis of molecular genetics and relates with the progression of the diseases. Central nervous system (CNS) tumours are among the most rapidly fatal of all cancers. It has been proposed that the progression of malignant tumours may result from multi-step of genetic alterations, including activation of oncogenes, inactivation of tumour suppressor genes and also the presence of certain molecular marker such as telomerase activity. In this paper, we review some recent data from the literature, including our own studies, on the molecular genetics analysis in CNS tumours. Our studies have shown that two types of tumour suppressor genes, p53 and PTEN were involved in the development of these tumours but not in p16 gene among the patients from Hospital Universiti Sains Malaysia (HUSM). Telomerase activity also has been detected in various types of CNS tumours. Thus, it is important to assemble all data which related to this study and may provide as a vital information in a new approach to neuro-oncology studies in Malaysia.
URI: http://hdl.handle.net/1807/7527
Other Identifiers: http://www.bioline.org.br/abstract?id=mj04004
Rights: Copyright 2004 - Malaysian Journal of Medical Science
Appears in Collections:Bioline International Legacy Collection

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