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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/7826

Title: Hyperhomocysteinemia as a risk factor for ischemic stroke: an Indian scenario
Authors: Modi, M.
Prabhakar, S.
Majumdar, S.
Khullar, M.
Lal, V.
Das, C. P.
Keywords: Case-control study; homocysteine; ischemic stroke.
Issue Date: 31-Dec-2005
Publisher: Medknow Publications on behalf of the Neurological Society of India
Citation: Neurology India (ISSN: 0028-3886) Vol 53 Num 3
Abstract: Background : Hyperhomocysteinemia has been proposed as an important risk factor for ischemic stroke worldwide, but data available from the Indian subcontinent is scarce. Aim : To study homocysteine levels in patients with ischemic stroke and compare it with age- and sex-matched controls. Settings and Design: Case-control prospective study. Materials and Methods: Fifty-seven patients with ischemic stroke and 30 controls were recruited for the study. They were subdivided into two subgroups (<40 years and >40 years of age) and plasma fasting total homocysteine (tHcy) levels were measured. Statistical analysis used: Student′s ′t′ test and chi-square test. Results: The tHcy were significantly high in patients with stroke, compared to controls (9.91 ± 2.25 vs 8.00 ± 2.74 mmol/l; P < 0.001). Significantly high levels were seen in both male patients compared to controls (10.24 ± 2.34 vs 8.45 ± 2.72 μmol/l; P = 0.01) and female patients compared to controls (9.08 ± 1.81 vs 6.79 ± 2.60 μmol/l; P = 0.04). The tHcy levels were significantly high in patients with hypertension compared to normotensive patients (10.96 vs 9.49 μmol/l; P = 0.01) and smokers compared to nonsmokers (11.17 vs 9.33 μol/l; P = 0.01). Conclusions : Hyperhomo-cysteinemia emerged as an important independent risk factor for ischemic stroke. A strong positive correlation was also observed between hypertension, smoking, and high-tHcy levels in the present study.
URI: http://hdl.handle.net/1807/7826
Other Identifiers: http://www.bioline.org.br/abstract?id=ni05103
Rights: Copyright 2005 Neurology India.
Appears in Collections:Bioline International Legacy Collection

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