|Title: ||Hyperhomocysteinemia as a risk factor for ischemic stroke: an Indian scenario|
|Authors: ||Modi, M.|
Das, C. P.
|Keywords: ||Case-control study; homocysteine; ischemic stroke.|
|Issue Date: ||31-Dec-2005|
|Publisher: ||Medknow Publications on behalf of the Neurological Society of India|
|Citation: ||Neurology India (ISSN: 0028-3886) Vol 53 Num 3|
|Abstract: ||Background : Hyperhomocysteinemia has been proposed as an important
risk factor for ischemic stroke worldwide, but data available from the
Indian subcontinent is scarce. Aim : To study homocysteine levels in
patients with ischemic stroke and compare it with age- and sex-matched
controls. Settings and Design: Case-control prospective study.
Materials and Methods: Fifty-seven patients with ischemic stroke and 30
controls were recruited for the study. They were subdivided into two
subgroups (<40 years and >40 years of age) and plasma fasting
total homocysteine (tHcy) levels were measured. Statistical analysis
used: Student′s ′t′ test and chi-square test.
Results: The tHcy were significantly high in patients with stroke,
compared to controls (9.91 ± 2.25 vs 8.00 ± 2.74 mmol/l; P
< 0.001). Significantly high levels were seen in both male patients
compared to controls (10.24 ± 2.34 vs 8.45 ± 2.72
μmol/l; P = 0.01) and female patients compared to controls (9.08
± 1.81 vs 6.79 ± 2.60 μmol/l; P = 0.04). The tHcy
levels were significantly high in patients with hypertension compared
to normotensive patients (10.96 vs 9.49 μmol/l; P = 0.01) and
smokers compared to nonsmokers (11.17 vs 9.33 μol/l; P = 0.01).
Conclusions : Hyperhomo-cysteinemia emerged as an important
independent risk factor for ischemic stroke. A strong positive
correlation was also observed between hypertension, smoking, and
high-tHcy levels in the present study.|
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=ni05103|
|Rights: ||Copyright 2005 Neurology India.|
|Appears in Collections:||Bioline International Legacy Collection|