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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/7888

Title: Early recombinant factor VIIa therapy in acute intracerebral hemorrhage: promising approach
Authors: Kumar, Sudhir
Badrinath, H.R.
Keywords: Recombinant factor VIIa, Acute intracerebral hemorrhage.
Issue Date: 31-Dec-2006
Publisher: Medknow Publications on behalf of the Neurological Society of India
Citation: Neurology India (ISSN: 0028-3886) Vol 54 Num 1
Abstract: Intracerebral hemorrhage (ICH) is the most devastating form of stroke with a high morbidity and mortality. ICH constitutes about 20-30% of all strokes, with the prevalence being higher in Asian population. Treatment of ICH is predominantly conservative, which includes control of blood pressure, use of anti-cerebral edema measures such as mannitol and mechanical ventilation. The benefit of early surgery in ICH is debatable. Initial hematoma volume and subsequent growth in its size are important predictors of a poor outcome in ICH. This means that therapies aimed at preventing hematoma enlargement in the earliest possible window period could lead to a better outcome in ICH. Recombinant factor VIIa (rFVIIa) is one such agent, which has been shown to prevent hematoma expansion and improve outcome in acute ICH. The purpose of the current review is to focus on the evidence regarding the usefulness of rFVIIa in acute ICH.
URI: http://hdl.handle.net/1807/7888
Other Identifiers: http://www.bioline.org.br/abstract?id=ni06004
Rights: Copyright 2006 Neurology India.
Appears in Collections:Bioline International Legacy Collection

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