|Title: ||Early recombinant factor VIIa therapy in acute
intracerebral hemorrhage: promising approach|
|Authors: ||Kumar, Sudhir|
|Keywords: ||Recombinant factor VIIa, Acute intracerebral hemorrhage.|
|Issue Date: ||31-Dec-2006|
|Publisher: ||Medknow Publications on behalf of the Neurological Society of India|
|Citation: ||Neurology India (ISSN: 0028-3886) Vol 54 Num 1|
|Abstract: ||Intracerebral hemorrhage (ICH) is the most devastating form of stroke
with a high morbidity and mortality. ICH constitutes about 20-30% of
all strokes, with the prevalence being higher in Asian population.
Treatment of ICH is predominantly conservative, which includes control
of blood pressure, use of anti-cerebral edema measures such as mannitol
and mechanical ventilation. The benefit of early surgery in ICH is
debatable. Initial hematoma volume and subsequent growth in its size
are important predictors of a poor outcome in ICH. This means that
therapies aimed at preventing hematoma enlargement in the earliest
possible window period could lead to a better outcome in ICH.
Recombinant factor VIIa (rFVIIa) is one such agent, which has been
shown to prevent hematoma expansion and improve outcome in acute ICH.
The purpose of the current review is to focus on the evidence regarding
the usefulness of rFVIIa in acute ICH.|
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=ni06004|
|Rights: ||Copyright 2006 Neurology India.|
|Appears in Collections:||Bioline International Legacy Collection|