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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/7943

Title: GASTRIC ULCEROGENIC ACTIVITIES OF Piper guineense   EXTRACT IN RATS
Authors: RajiAJI, Y.
Udoh, U. S.
Ojo, O. O.
Keywords: Piper guineense, ulceration, rats
Issue Date: 31-Dec-2003
Publisher: Physiological Society of Nigeria
Citation: Nigerian Journal of Physiological Sciences (ISSN: 0794-859X) Vol 18 Num 1-2
Abstract: Administration of Piper guineense   fruit extract caused a dose - dependent mortality rate in rats. Doses of 200 mgkg-1 intravenously, (i.v); 300 mgkg-1 intraperitoneally, (i.p) and 3200 mgkg-1 orally( p.o) produced 100% mortality rate - giving LD50 of 85.1 mgkg-1 i.v ; 224 mgkg i.p and 1122 mgkg-1 p.o respectively. Piper extract significantly stimulated gastric ulceration, total gastric acidity and in situ gastric acid secretion in rats. Piper-induced gastric ulceration appears to be similar to that induced by indomethacin (40 mgkg-1 b.w). Atropine produced no effect on the stimulatory action of piper on gastric acid secretion. However, gastric acid secretion in the presence of histamine, and cimetidine appears to be augmented by piper extract (25 mgkg-1 b.w). The results suggest that piper could stimulate gastric acid secretion (and probably gastric ulceration) via the H2 - receptor potentiation.
URI: http://hdl.handle.net/1807/7943
Other Identifiers: http://www.bioline.org.br/abstract?id=np03007
Rights: Copyright 2003 - Physiological Society of Nigeria
Appears in Collections:Bioline International Legacy Collection

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