|Title: ||GASTRIC ULCEROGENIC ACTIVITIES OF Piper guineense EXTRACT IN
|Authors: ||RajiAJI, Y.|
Udoh, U. S.
Ojo, O. O.
|Keywords: ||Piper guineense, ulceration, rats|
|Issue Date: ||31-Dec-2003|
|Publisher: ||Physiological Society of Nigeria|
|Citation: ||Nigerian Journal of Physiological Sciences (ISSN: 0794-859X) Vol 18 Num 1-2|
|Abstract: ||Administration of Piper guineense fruit extract caused a dose
- dependent mortality rate in rats. Doses of 200 mgkg-1 intravenously,
(i.v); 300 mgkg-1 intraperitoneally, (i.p) and 3200 mgkg-1 orally( p.o)
produced 100% mortality rate - giving LD50 of 85.1 mgkg-1 i.v ; 224
mgkg i.p and 1122 mgkg-1 p.o respectively. Piper extract significantly
stimulated gastric ulceration, total gastric acidity and in situ
gastric acid secretion in rats. Piper-induced gastric ulceration
appears to be similar to that induced by indomethacin (40 mgkg-1 b.w).
Atropine produced no effect on the stimulatory action of piper on
gastric acid secretion. However, gastric acid secretion in the presence
of histamine, and cimetidine appears to be augmented by piper extract
(25 mgkg-1 b.w). The results suggest that piper could stimulate gastric
acid secretion (and probably gastric ulceration) via the H2 - receptor
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=np03007|
|Rights: ||Copyright 2003 - Physiological Society of Nigeria|
|Appears in Collections:||Bioline International Legacy Collection|