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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/8072

Title: Increased Plasma Levels of Tumor Necrosis Factor-α in Asymptomatic/“Indeterminate” and Chagas Disease Cardiomyopathy Patients
Authors: Ferreira, Renata Cristina
Ianni, Barbara M.
Abel, Lucia C. J.
Buck, Paula
Mady, Charles
Kalil, Jorge
Cunha-Neto, Edecio
Keywords: Chagas disease cardiomyopathy - tumor necrosis factor-alpha - Trypanosoma cruzi
Issue Date: 31-Dec-2003
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 98 Num 3
Abstract: We compared plasma tumor necrosis factor-α (TNF-α) levels among asymptomatic/"indeterminate" Chagas disease patients (ASY) and patients across the clinical spectrum of chronic Chagas disease cardiomyopathy (CCC). Idiopathic dilated cardiomyopathy (DCM) patients and normal controls (NC) were included as controls. ASY Chagas disease patients had significantly higher plasma TNF-α levels than NC. TNF-α levels among severe CCC patients with significant left ventricular (LV) dysfunction were similar to those of DCM patients, showing average 2-fold higher levels than CCC patients without LV dysfunction and ASY patients, and 8-fold higher levels than NC. In Chagas disease, chronic TNF-α production prior to heart failure may play a role in CCC progression.
URI: http://hdl.handle.net/1807/8072
Other Identifiers: http://www.bioline.org.br/abstract?id=oc03091
Rights: Copyright 2003 - Instituto Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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