|Title: ||Increased Plasma Levels of Tumor Necrosis Factor-α in
Asymptomatic/“Indeterminate” and Chagas Disease Cardiomyopathy Patients|
|Authors: ||Ferreira, Renata Cristina|
Ianni, Barbara M.
Abel, Lucia C. J.
|Keywords: ||Chagas disease cardiomyopathy - tumor necrosis factor-alpha -
|Issue Date: ||31-Dec-2003|
|Publisher: ||Fundação Oswaldo Cruz, Fiocruz|
|Citation: ||Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 98 Num 3|
|Abstract: ||We compared plasma tumor necrosis factor-α (TNF-α) levels
among asymptomatic/"indeterminate" Chagas disease patients (ASY) and
patients across the clinical spectrum of chronic Chagas disease
cardiomyopathy (CCC). Idiopathic dilated cardiomyopathy (DCM) patients
and normal controls (NC) were included as controls. ASY Chagas disease
patients had significantly higher plasma TNF-α levels than NC.
TNF-α levels among severe CCC patients with significant left
ventricular (LV) dysfunction were similar to those of DCM patients,
showing average 2-fold higher levels than CCC patients without LV
dysfunction and ASY patients, and 8-fold higher levels than NC. In
Chagas disease, chronic TNF-α production prior to heart failure
may play a role in CCC progression.|
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=oc03091|
|Rights: ||Copyright 2003 - Instituto Oswaldo Cruz - Fiocruz|
|Appears in Collections:||Bioline International Legacy Collection|