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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/8198

Title: Lipoxin agonists: turn right! to path of resolving neutrophil
Authors: Devchand, Pallavi R.
Keywords: neutrophil - lipid mediators - resolution of inflammation
Issue Date: 31-Dec-2005
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 100 Num s1
Abstract: An impressive array of cellular and molecular adaptive responses achieves homeostasis. The inflammatory reaction is an adaptive response triggered by an insult to culminate into the overt cardinal signs of inflammation, eventually leading to resolution and returning the organism back to its original centered state. This article focuses on some aspects of the lipoxin A4 signaling pathway during the resolution phase, to better understand molecular mechanisms by which a neutrophil directs an inflammatory reaction to switch off and resume homeostasis. Defining the resolution state of a neutrophil at the molecular level will aid in treatments of diseases that are associated with an exaggerated and uncontrolled inflammation.
URI: http://hdl.handle.net/1807/8198
Other Identifiers: http://www.bioline.org.br/abstract?id=oc05027
Rights: Copyright 2005 - Instituto Oswaldo Cruz - Fiocruz.
Appears in Collections:Bioline International Legacy Collection

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