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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/8262

Title: Slime production and proteinase activity of Candida species isolated from blood samples and the comparison of these activities with minimum inhibitory concentration values of antifungal agents
Authors: Ozkan, Semiha
Kaynak, Fatma
Kalkanci, Ayse
Abbasoglu, Ufuk
Kustimur, Semra
Keywords: slime - proteinase activity - Candida spp. - antifungal susceptibility - minimum inhibitory concentration - blood samples
Issue Date: 31-Dec-2005
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 100 Num 3
Abstract: Slime and proteinase activity of 54 strains consisting of 19 Candida parapsilosis and 35 Candida albicans strains isolated from blood samples were investigated in this study. Ketoconazole, amphothericin B, and fluconazole susceptibility of Candida species were compared with slime production and proteinase activity of these species. For both Candida species, no correlation was detected between the slime activity and minimum inhibitory concentration (MIC) values of the three antifungal agents. For both Candida species no correlation was detected between the proteinase activity and the MIC values of amphothericin B, and fluconazole however, statistically significant difference, was determined between the proteinase activity and MIC values of ketoconazole (p = 0.007). Slime production was determined by using modified Christensen macrotube method and proteinase activity was measured by the method of Staib. Antifungal susceptibility was determined through the guidelines of National Committee for Laboratory Standards (NCCLS M27-A).
URI: http://hdl.handle.net/1807/8262
Other Identifiers: http://www.bioline.org.br/abstract?id=oc05091
Rights: Copyright 2005 Instituto Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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