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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/8301

Title: Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs
Authors: Fernandes Júnior, Ary
Balestrin, Elaine Cristina
Betoni, Joyce Elaine Cristina
Orsi, Ricardo de Oliveira
da Cunha, Maria de Lourdes Ribeiro de Souza
Montelli, Augusto Cezar
Keywords: Staphylococcus aureus - Kirby and Bauer method - E-test method - antimicrobial drugs
Issue Date: 31-Dec-2005
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 100 Num 5
Abstract: Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E-Test) on 25 S. aureus strains was evaluated. Petri dishes with sub-inhibitory concentrations of EEP were incubated with 13 drugs using Kirby and Bauer method and synergism between EEP and five drugs [choramphenicol (CLO), gentamicin (GEN), netilmicin (NET), tetracycline (TET), and vancomycin (VAN)] was observed. Nine drugs were assayed by the E-test method and five of them exhibited a synergism [CLO, GEN, NET, TET, and clindamycin (CLI)]. The results demonstrated the synergism between EEP and antimicrobial drugs, especially those agents that interfere on bacterial protein synthesis.
URI: http://hdl.handle.net/1807/8301
Other Identifiers: http://www.bioline.org.br/abstract?id=oc05130
Rights: Copyright 2005 - Instituto Oswaldo Cruz - Fiocruz.
Appears in Collections:Bioline International Legacy Collection

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