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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/8461

Title: Tumor Necrosis Factor-a in Human American Tegumentary Leishmaniasis
Authors: Da-Cruz, Alda Maria
Pereira de Oliveira, Marcia
Mello De Luca, Paula
Mendonca, Sergio C. F.
Coutinho, Sergio G.
Keywords: TNF-alpha cytokine tegumentary leishmaniasis Leishmania braziliensis
Issue Date: 31-Dec-1996
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 91 Num 2
Abstract: Tumor necrosis factor-alpha (TNF-alpha) is a cytokine produced by activated macrophages and other cells. In order to verify whether the serum levels of TNF-alpha in American tegumentary leishmaniasis patients are associated with the process of cure or aggravation of the disease, 41 patients were studied: 26 cases of cutaneous leishmaniasis (CL) and 15 of mucocutaneous leishmaniasis (MCL). During active disease the serum levels of TNF-alpha of MCL patients were significantly higher than those of CL patients and control subjects (healthy individuals and cutaneous lesions from other etiologies). The MCL patients had serum titers of TNF-alpha significantly lower at the end of antimonial therapy than before therapy. After a six-month follow-up, the MCL patients had serum levels of TNF-alpha similar to those observed at the end of the therapy as well as to those of CL patients and control subjects. No significant variation in the serum levels of TNF-alpha was observed in CL patients throughout the study period (before, at the end of therapy and after a six-month follow-up). The possible relationship between the high TNF-alpha serum levels and severity of the disease is discussed.
URI: http://hdl.handle.net/1807/8461
Other Identifiers: http://www.bioline.org.br/abstract?id=oc96044
Rights: Copyright 1996 Fundacao Oswaldo Cruz
Appears in Collections:Bioline International Legacy Collection

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