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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/8517

Title: Original Article - Sister-chromatid exchanges in anesthetists
Authors: Jayakara, F.
Thomas, I. M.
Keywords: Anesthetic gases, Anesthetists, Genotoxicity, Sister-chromatid exchanges
Issue Date: 31-Dec-2005
Publisher: Medknow Publications
Citation: Indian Journal of Occupational and Environmental Medicine (ISSN: 0973-2284) Vol 9 Num 2
Abstract: A number of reports indicate that waste anesthetic gases (AG) that are ambient in the operation theater (OT) are responsible for producing effects in anesthetists like headaches, dizziness, nausea, heart and liver diseases, cancer as well as poor obstetric history for the female staff. To evaluate the presence or absence of genotoxicity. Because sister-chromatid exchanges (SCE) are sensitive indicators of exposure to mutagens, the blood of 51 anesthetists and 51 stringently matched controls were cultured and harvested and analyzed. (1) Descriptive statistics - mean, range and standard deviation. (2) Inferential statistical procedures: (a) univariate procedures and (b) multivariate procedures (step-wise multiple regression analysis). The results showed a significantly higher level of SCE (7.68 ± 2.03/cell) in anesthetists when compared to that of controls (5.78 ± 1.23/cell), demonstrating that a genotoxic effect is present. There is a strong case for installing scavenging devices and leak-proof apparatus in the OT to lower the level of ambient AG, because the health of all OT staff is at risk.
URI: http://hdl.handle.net/1807/8517
Other Identifiers: http://www.bioline.org.br/abstract?id=oe05020
Rights: Copyright 2005 Indian Journal of Occupational and Environmental Medicine.
Appears in Collections:Bioline International Legacy Collection

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