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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/8790

Title: Bactericidal activity of manganese (IV) complex of 2-methylamino-pyridine against Streptococcus pyogenes and Staphylococcus aureus
Authors: El-Masry, S.
El-Sayed, I.H.
Lotfy, M.
El-Shahat, M.
Ali, S.A.
Nasif, W.A.
Keywords: Free radicals, gram-positive cocci, metal complex, SOD.
Issue Date: 31-Dec-2006
Publisher: Medknow Publications on behalf of Indian Pharmacological Society
Citation: Indian Journal of Pharmacology (ISSN: 0253-7613) Vol 38 Num 3
Abstract: Objective: To investigate the bactericidal activity of manganese (IV) complex of 2-methylamino-pyridine against Streptococcus pyogenes ( S. pyogenes ) and Staphylococcus aureus ( S. aureus ). Materials and Methods: The inhibitory effect of the complex was studied on the molecular level and by turbidity measurement. Treatment of bacteria was carried out using 5, 10, 25, 50 and 100 ┬Ámol of the complex per ml of culture media. Results: The results showed that the growth of S. pyogenes rapidly decreased with increasing concentrations of the complex. In contrast, the complex caused no significant decrease in the growth rate of S. aureus . The molecular level studies showed that four protein bands, with apparent molecular weights of 19, 23, 30 and 54 Kda, respectively, increased in the protein pattern of the S. pyogenes extract after the complex treatment using silver stained polyacrylamide gels, under reducing condition . However, there was no detectable change in the protein pattern of the S. aureus extract after the complex treatment . No DNA damage was detected while using agarose gel electrophoresis and ethidium bromide staining in both types of bacteria. Conclusion: Manganese (IV) complex of 2-methylamino-pyridine showed an apparent antibacterial inhibitory effect against S. pyogenes, but S. aureus was apparently resistant.
URI: http://hdl.handle.net/1807/8790
Other Identifiers: http://www.bioline.org.br/abstract?id=ph06043
Rights: Copyright 2006 Indian Journal of Pharmacology.
Appears in Collections:Bioline International Legacy Collection

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