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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/9256

Title: Detección de interacciones medicamentosas, en pacientes ingresados a la unidad de cuidados intensivos del Instituto Autónomo Hospital Universitario de los Andes ( Serie Clínica ) (Detection of drugs interactions in patients hospitalized in the intensive care unit of the autonomus Institute University Hospital of the Andes (Clinical series))
Authors: Bustamante, Galetta
Calderón de Cabrera, Douglas Doménico
Gabriela, Lourdes Durán de G. M.
José, Núñez Medina Tulio
Keywords: Drug Interactions, Kinetic medicinal, dynamic medicinal.
Interacción medicamentosa / farmacocinética / farmacodinámica.
Issue Date: 31-Dec-2005
Publisher: Centro de Análisis de Imágenes Biomédicas Computarizadas-CAIBC0
Citation: VITAE Academia Biomédica Digital (ISSN: 1317-987x) Num 25
Abstract: A series study was made of clinical cases to detect drug interactions in patients hospitalized in the Intensive Care Unit of University Hospital of the Andes since June 1st to august 31st 2003. Thirty five patients hospitalized were studied to be treated at least during twenty four hours. The medicines used in the therapy were collected in a format and through an interactive software program of computerized data recorded as: Medicinal Interactions Statistical Basis " TOXI – MED " Carlex Corporation version 1.1 1994, we found: The medicines which interact, kind of interaction, more important clinician effects as well as the severity it self. 116 Medicinal Interactions were detected in 86 %. Were kinetic medicinal the 55.2 % and dynamic medicinal 44.8% with an average from 6.7 ± 1.9 drugs for patients. The average age 38.5 ± 19.6 years, with a higher percent in 24 – 64 years (60 %) and limited ages between 14 and 86 years. The masculine sex represented (51.4 %); From the medicinal interactions of which clinically important, 20 % and 7 % of the kinetic medicinal and dynamic medicinal respectively, were classified as severe. The medications more used in order of frequency they were: Benzodiacepine - morfine (20.0 %), fenytoine - morfine (14.2 %) followed by 8.6 % for each one betabloquer - benzodiacepine, aspirine - antihypertensive and aminoglucoside –morfine. The central nervous system was the most affected (34.28 %). With this results we contribute the basis to fix a rational approach in the use of several simultaneous medicines with a frequent use in Intensive Therapy.
URI: http://hdl.handle.net/1807/9256
Other Identifiers: http://www.bioline.org.br/abstract?id=va05019
Rights: Copyright 2005 - Centro de Análisis de Imágenes Biomédicas Computarizadas CAIBCO, Instituto de Medicina Tropical - Facultad de Medicina, Universidad Central de Venezuela
Appears in Collections:Bioline International Legacy Collection

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